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Catalog	name	Description	price
R-C-1726	Vemurafenib (PLX4032) CAS:918504-65-1	Vemurafenib(PLX4032,RG7204,RO5185426)is a novel and potent inhibitor of B-RafV600E with IC50 of 31 nM in cell-free assay.10-fold selective for B-RafV600E over wild-type B-Raf in enzymatic assays and the cellular selectivity can exceed 100-fold.Vemurafenib(PLX4032,RG7204)induces autophagy.	price>
R-C-1739	AS 602801 CAS:848344-36-5	Bentamapimod(AS 602801)is an ATP-competitive JNK inhibitor with IC50 of 80 nM,90 nM,and 230 nM for JNK1,JNK2,and JNK3,respectively.	price>
R-C-1767	Pexmetinib(ARRY-614) CAS:945614-12-0	Pexmetinib is a potent inhibitor of cytokine synthesis,via the dual inhibition of p38 mitogen-activated protein kinase(MAPK),and Tie2/Tek receptor tyrosine kinase.	price>
R-C-1784	Acumapimod (BCT-197) CAS:836683-15-9	Acumapimod(BCT197)is an orally active p38 MAP kinase inhibitor,with an IC50 of less than 1 μM for p38α.	price>
R-C-1794	PLX8394 CAS:1393466-87-9	PLX8394 is a next-generation,orally available,small-molecule BRAF inhibitor with IC50 values of 3.8 nM,14 nM and 23 nM for BRAF(V600E),WT BRAF and CRAF respectively.It has potential antineoplastic activity.	price>
R-C-1798	OTS514 CAS：1338540-63-8	OTS514,a thieno[2,3-c]quinolone compound,is a highly potent TOPK inhibitor with an IC50 value of 2.6 nM.The compound can inhibit TOPK kinase activity.	price>
R-C-1799	OTS964 CAS：1338545-07-5	OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM.OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.	price>
R-C-1805	Lifirafenib (BGB-283) CAS：1446090-79-4	Lifirafenib(BGB-283,Beigene-283)potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23,29 and 495 nM for the recombinant BRAFV600E kinase domain,EGFR and EGFR T790M/L858R mutant.	price>
R-C-1809	B-Raf inhibitor 1 CAS:1093100-40-3	Raf inhibitor 1 is a potent Raf kinase inhibitor with Kis of 1 nM,1nM,and 0.3 nM for B-RafWT,B-RafV600E,and C-Raf,respectively.	price>
R-C-1810	Agerafenib (RXDX-105) CAS:1188910-76-0	CEP-32496 is an orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf)serine/threonine protein kinase inhibitor with potential antineoplastic activity.	price>

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