Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3254	Cerlapirdine CAS No.925448-93-7	Cerlapirdine (SAM-531, PF-05212365)/CAS No.925448-93-7 is a selective and potent full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor.	price>
R-R-3255	Usmarapride CAS No.1428862-33-2	Usmarapride (SUVN-D4010)/CAS No.1428862-33-2 is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM).	price>
R-R-3256	Usmarapride free base CAS No.1428862-32-1	Usmarapride (SUVN-D4010) free base/CAS No.1428862-32-1 is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM).	price>
R-R-3257	Ampreloxetine CAS No.1227056-84-9	Ampreloxetine (TD-9855)/CAS No.1227056-84-9 is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine has the potential for the research of neurogenic orthostatic hypotension.	price>
R-R-3258	Amitriptyline-d6 hydrochloride CAS No.203645-63-0	Amitriptyline-d6 (hydrochloride)/CAS No.203645-63-0 is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.	price>
R-C-1559	CCG215022 CAS：1813527-81-9	CCG215022 is a potent GRK2 and GRK5 inhibitor.CCG215022 exhibited nanomolar IC50 values against both GRK2 and GRK5 and good selectivity against other closely related kinases such as GRK1 and PKA.	price>
R-R-3259	m-CPBG hydrochloride CAS No.2113-05-5	m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride/CAS No.2113-05-5 is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease.	price>
R-R-3260	RS 39604 CAS No.167710-87-4	RS 39604/CAS No.167710-87-4 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. RS 39604 displays a low affinity (pKi<6.5) for 5-HT1A, 5-HT2C, 5-HT3, α1c, D1, D2, M1, M2, AT1, B1 and opioid mu receptors and moderate affinity for δ1, (pKi=6.8) and δ2 (pKi=7.8) sites.	price>
R-R-3261	Quetiapine-d4 hemifumarate CAS No.1217310-65-0	Quetiapine-d4 (hemifumarate)/CAS No.1217310-65-0 is the deuterium labeled Quetiapine hemifumarate. Quetiapine hemifumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects.	price>
R-R-3262	WAY-100135 dihydrochloride CAS No.149055-79-8	WAY-100135 dihydrochloride/CAS No.149055-79-8 is a selective antagonist at presynaptic and postsynaptic 5-HT1A receptor, with an IC50 of 34 nM at the rat hippocampal 5-HT1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties.	price>

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